Sino-Biocan launches WUKONG Automated, Closed, Integrated Cell Processing System

Shanghai, October 2024 — The advent of cell therapy drugs has unlocked new possibilities for curing a wide range of malignant diseases. At the same time, the growing adoption of automated and intelligent cell preparation technologies is set to significantly accelerate the global implementation of cell therapies. In response to this expanding trend, Sino-Biocan has launched the self-developed WUKONG Automated, Closed, Integrated Cell Processing System, building on its existing modular cell preparation platforms. This state-of-the-art system features continuous, fully automated, closed-loop, and intelligent capabilities, enabling efficient and autonomous operation. It is designed to meet the needs of hospitals for clinical trial (IIT) cell drug preparation, bedside cell therapy, as well as the process development and manufacturing requirements of pharmaceutical R&D companies and Contract Development and Manufacturing Organizations (CDMOs). The launch of this innovative product, with independent intellectual property rights, marks a significant milestone in Sino-Biocan’s commitment to a “self-controlled, high-quality development path.” It demonstrates that Chinese cell preparation technologies have reached international standards, offering safe, efficient, and systematic solutions to leading global cell therapy providers.

WUKONG Automated, Closed, Integrated Cell Processing System: A Comprehensive Solution for Cell Preparation

WUKONG Automated, Closed, Integrated Cell Processing System offers a fully integrated workflow solution, covering the entire process from blood collection to cell drug production. This includes PBMC separation and cell filling, ensuring seamless integration across all stages. Particularly, the highly automated system enables automatic cell filling without manual intervention and pumps excess cells into designated bags, improving operational efficiency.

The system is designed to continuously monitor key parameters such as pH and dissolved oxygen (DO) in real time, ensuring the stability and safety of the cell preparation process. Equipped with 36 tube valves, the system offers exceptional flexibility to accommodate complex workflows and can intelligently adjust oxygen supply levels based on DO values, optimizing the culture environment.

Tailored for customization, Wukong system allows users to configure various cell preparation protocols. It is compatible with both nano and micron-sized magnetic beads, catering to diverse application needs. Once reagents are loaded, the system automatically integrates processes like cell sorting, viral transduction, cell culture, and filling, streamlining the entire operation. Real-time parameter displays and barcode traceability ensure complete transparency and facilitate backward tracking. All operational data and process steps are automatically recorded, generating detailed reports for quality control and data analysis.

Moreover, the closed design, which operates with single-use consumables, reduces the need for cleanroom space, ensuring both safety and efficiency in cell preparation.

Key Features:

· Integrated Platform System: Consolidates the complex cell therapy laboratory process into a single platform, streamlining operations with automated control to simplify workflows.

· Full-Process Automation: Automates the entire workflow—from cell separation, sorting, transduction, and cultivation to concentration, washing, and filling—within one device, enhancing operational efficiency.

· Fully Intelligent Control System: Continuously records and analyzes production data in real-time, ensuring process traceability and improving reliability through heightened automation.

· Closed System Tubing System: Reduces the risk of human error and contamination, safeguarding the integrity and effectiveness of the cell preparation process.

· Fully Automated Cell Processing: Enhances experimental efficiency and accuracy, ensuring reproducibility in GMP-grade cell preparation.

· Disposable Sterile Cell Kits: Provides a fully closed environment for cell preparation, with production and packaging processes strictly adhering to GMP standards.

Professional Training and Global Client Recognition

Following the product launch, customers from around the world visited Sino-Biocan’s production facility in Shanghai for product acceptance and professional training. During this process, clients had the opportunity to experience firsthand the full capabilities of Wukong system and explore its vast potential applications in the field of cell preparation. Sino-Biocan’s expert team provided detailed demonstrations, ensuring clients gained a comprehensive understanding of both the operation and maintenance of the equipment. The feedback was overwhelmingly positive, with clients particularly emphasizing that the high level of automation and ease of use would significantly enhance their operational efficiency in the cell therapy space.

To help clients maximize the benefits of this advanced technology, Sino-Biocan organized a comprehensive, multi-day training program covering the full cell preparation workflow—from separation and cultivation to transduction. This hands-on training, combining theoretical instruction with practical experience, allowed clients to gain a deeper understanding of the system’s capabilities and ensured they would achieve optimal results in their future cell preparation processes.

International Recognition – Award for Design Innovation

WUKONG Automated, Closed, Integrated Cell Processing System was notably awarded the prestigious Good Design Award in recognition of its outstanding design and technological innovation. Since its inception in 1950, the Good Design Award has recognized products for excellence in design and functionality, with criteria including innovation, usability, aesthetics, and sustainability. This recognition underscores Sino-Biocan’s leadership in the cell preparation automation space and affirms its commitment to advancing the industry with cutting-edge solutions.

Conclusion

The launch of Sino-Biocan’s WUKONG Automated, Closed, Integrated Cell Processing System marks a significant leap forward in the cell preparation automation industry, offering global customers a more efficient and secure solution. With strong feedback from international clients and widespread recognition, Sino-Biocan has demonstrated its innovative capabilities and market potential, positioning China at the forefront of the global cell preparation automation sector.

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